Malignant Pleural Mesothelioma Mpm Pipeline Insight
DelveInsight’s, “Malignant Pleural Mesothelioma (MPM) - Pipeline Insight, 2022,” report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Malignant Pleural Mesothelioma (MPM) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Global coverage
Malignant Pleural Mesothelioma (MPM) Understanding
Malignant Pleural Mesothelioma (MPM): Overview
Malignant pleural mesothelioma (MPM) is an aggressive cancer of the pleural surface. It is associated with previous asbestos exposure, with a latency period of ?40 years between fibre exposure and disease presentation. Global incidence of MPM has risen steadily over the past decade, and is predicted to continue to an estimated peak in 2020. Prognosis with MPM is poor and median survival ranges from 8 to 14 months from diagnosis. Women have a more favourable outlook than men, but due to the occupational nature of the disease there is a male predominance of 4:1. There are four main histological sub-types; epithelioid, sarcomatoid, biphasic or mixed, and desmoplastic. The majority of MPM cases are caused by prior exposure to asbestos, often occurring >40 years previously. Other causes of MPM include erionite (a mineral found in the rocks of Turkey), chest wall radiation and simian virus
"Malignant Pleural Mesothelioma - Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Malignant Pleural Mesothelioma pipeline landscape is provided which includes the disease overview and Malignant Pleural Mesothelioma treatment guidelines. The assessment part of the report embraces, in depth Malignant pleural mesothelioma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Malignant Pleural Mesothelioma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
The companies and academics are working to assess challenges and seek opportunities that could influence Malignant pleural mesothelioma R&D. The therapies under development are focused on novel approaches to treat/improve Malignant pleural mesothelioma.
Malignant Pleural Mesothelioma Emerging Drugs Chapters
This segment of the Malignant Pleural Mesothelioma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Malignant Pleural Mesothelioma Emerging Drugs
NGR-TNF: MolMed
NGR-TNF is a recombinant protein that allows to increase the concentration of immunity cells and chemotherapeutic drugs at the tumour level through the permeabilization of tumour vessels. NGR-LTNF is currently being investigated in Phase 3 stage of development for the treatment of Malignant Pleural Mesothelioma.
Pembrolizumab : Merck & Co
Pembrolizumab, a programmed cell death 1 (PD-1)-blocking antibody, is being used with increasing frequency for solid tumors positive for the programmed cell death ligand 1 (PD-L1) biomarker. There have been reports of antitumor activity in several malignancies with increased PD-L1 expression, including non-small-cell lung cancer. While recent reports have shown remarkable clinical improvement from salvage immunotherapy in cases of advanced malignant pleural mesothelioma (MPM).
Pegargiminase: Polaris Pharmaceuticals
Pegargiminase, a novel targeted cancer therapy that depletes circulating arginine in combination with standard chemotherapies and immuno-oncology drugs in various cancers, including hepatocellular carcinoma and mesothelioma. Pegargiminase (ADI-PEG 20) is a potential first-in-class targeted cancer therapy in late-stage clinical development for a wide range of cancers, including hepatocellular carcinoma (HCC) and malignant pleural mesothelioma (MPM). Pegargiminase is well tolerated, both as a monotherapy and as part of a combination therapy.
Lurbinectedin: PharmaMar
Lurbinectedin, also known as PM01183, or commercially where approved as Zepzelca® is an analogue of a similar natural compound ET-736 with characteristics that make it similar but different to its parent compounds. Lurbinectedin inhibits active transcription of protein-coding genes through binding to promoters and irreversibly stalling elongating RNA polymerase II on the DNA template, thereby leading to double-stranded DNA breaks and apoptosis.
YS110: Ys Therapeutics
YS110 is a recombinant humanized monoclonal antibody that binds with high affinity (dissociation constant, 0.244?nM) to human CD26. Extensive in vitro and in vivo studies have shown that YS110 possesses antitumor activity for malignant mesothelioma cell lines. Single or repeated intravenous administration of YS110 has also been found to be safe in nonhuman primates.YS110 is currently being investigated in Phase1/2 for the treatment of Malignant Pleural Mesothelioma.
Further product details are provided in the report……..
Malignant Pleural Mesothelioma: Therapeutic Assessment
This segment of the report provides insights about the different Malignant Pleural Mesothelioma drugs segregated based on following parameters that define the scope of the report, such as:
Major Players in Malignant Pleural Mesothelioma
There are approx. 20+ key companies which are developing the therapies for Malignant pleural mesothelioma. The companies which have their Malignant pleural mesothelioma drug candidates in the most advanced stage, i.e. phase III include, MolMed.
Phases
DelveInsight’s report covers around 20+ products under different phases of clinical development like
Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates
Route of Administration
Malignant Pleural Mesothelioma (MPM) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Oral
Parenteral
Intravitreal
Subretinal
Topical
Molecule Type
Products have been categorized under various Molecule types such as
Monoclonal Antibody
Peptides
Polymer
Small molecule
Gene therapy
Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
Malignant Pleural Mesothelioma (MPM): Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Malignant Pleural Mesothelioma (MPM) Therapeutic Market by key players involved in developing emerging drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Malignant Pleural Mesothelioma (MPM) drugs.
Malignant Pleural Mesothelioma (MPM) Report Insights
Malignant Pleural Mesothelioma (MPM) Pipeline Analysis
Therapeutic Assessment
Unmet Needs
Impact of Drugs
Malignant Pleural Mesothelioma (MPM) Report Assessment
Pipeline Product Profiles
Therapeutic Assessment
Pipeline Assessment
Inactive drugs assessment
Unmet Needs
Key Questions
Current Treatment Scenario and Emerging Therapies:
How many companies are developing Malignant Pleural Mesothelioma (MPM) drugs?
How many Malignant Pleural Mesothelioma (MPM) drugs are developed by each company?
How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Malignant Pleural Mesothelioma (MPM)?
What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Malignant Pleural Mesothelioma (MPM) therapeutics?
What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
What are the clinical studies going on for Malignant Pleural Mesothelioma (MPM) and their status?
What are the key designations that have been granted to the emerging drugs?
Share:
Introduction
Executive Summary
Malignant pleural mesothelioma: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Malignant pleural mesothelioma – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
Comparative Analysis
Pembrolizumab: Merck & Co
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Lurbinectedin: PharmaMar
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
DrugName: Company Name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
Drug Name: Company name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Malignant pleural mesothelioma Key Companies
Malignant pleural mesothelioma Key Products
Malignant pleural mesothelioma- Unmet Needs
Malignant pleural mesothelioma- Market Drivers and Barriers
Malignant pleural mesothelioma- Future Perspectives and Conclusion
Malignant pleural mesothelioma Analyst Views
Malignant pleural mesothelioma Key Companies
Appendix
List of Table
Table 1: Total Products for Malignant Pleural Mesothelioma (MPM)
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Malignant Pleural Mesothelioma (MPM)
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• MolMed
• PharmaMar
• Ys Therapeutics
• Merck Sharp & Dohme Corp.
• Kissei Pharmaceutical Co., Ltd.
• NovoCure Ltd
• AGC Biologics S.p.A
• Aduro Biotech, Inc
• Novartis
• Bristol-Myers Squibb
• Novartis
• TCR2 Therapeutics
• Novotech (Australia) Pty Limited
• AstraZeneca
• Hoffmann-La Roche
• Polaris Pharmaceuticals
• Kyorin Pharmaceuticals
• ACADIA Pharmaceuticals
Request Customization
DelveInsight’s, “Malignant Pleural Mesothelioma (MPM) - Pipeline Insight, 2022,” report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Malignant Pleural Mesothelioma (MPM) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Global coverage
Malignant Pleural Mesothelioma (MPM) Understanding
Malignant Pleural Mesothelioma (MPM): Overview
Malignant pleural mesothelioma (MPM) is an aggressive cancer of the pleural surface. It is associated with previous asbestos exposure, with a latency period of ?40 years between fibre exposure and disease presentation. Global incidence of MPM has risen steadily over the past decade, and is predicted to continue to an estimated peak in 2020. Prognosis with MPM is poor and median survival ranges from 8 to 14 months from diagnosis. Women have a more favourable outlook than men, but due to the occupational nature of the disease there is a male predominance of 4:1. There are four main histological sub-types; epithelioid, sarcomatoid, biphasic or mixed, and desmoplastic. The majority of MPM cases are caused by prior exposure to asbestos, often occurring >40 years previously. Other causes of MPM include erionite (a mineral found in the rocks of Turkey), chest wall radiation and simian virus
"Malignant Pleural Mesothelioma - Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Malignant Pleural Mesothelioma pipeline landscape is provided which includes the disease overview and Malignant Pleural Mesothelioma treatment guidelines. The assessment part of the report embraces, in depth Malignant pleural mesothelioma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Malignant Pleural Mesothelioma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
The companies and academics are working to assess challenges and seek opportunities that could influence Malignant pleural mesothelioma R&D. The therapies under development are focused on novel approaches to treat/improve Malignant pleural mesothelioma.
Malignant Pleural Mesothelioma Emerging Drugs Chapters
This segment of the Malignant Pleural Mesothelioma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Malignant Pleural Mesothelioma Emerging Drugs
NGR-TNF: MolMed
NGR-TNF is a recombinant protein that allows to increase the concentration of immunity cells and chemotherapeutic drugs at the tumour level through the permeabilization of tumour vessels. NGR-LTNF is currently being investigated in Phase 3 stage of development for the treatment of Malignant Pleural Mesothelioma.
Pembrolizumab : Merck & Co
Pembrolizumab, a programmed cell death 1 (PD-1)-blocking antibody, is being used with increasing frequency for solid tumors positive for the programmed cell death ligand 1 (PD-L1) biomarker. There have been reports of antitumor activity in several malignancies with increased PD-L1 expression, including non-small-cell lung cancer. While recent reports have shown remarkable clinical improvement from salvage immunotherapy in cases of advanced malignant pleural mesothelioma (MPM).
Pegargiminase: Polaris Pharmaceuticals
Pegargiminase, a novel targeted cancer therapy that depletes circulating arginine in combination with standard chemotherapies and immuno-oncology drugs in various cancers, including hepatocellular carcinoma and mesothelioma. Pegargiminase (ADI-PEG 20) is a potential first-in-class targeted cancer therapy in late-stage clinical development for a wide range of cancers, including hepatocellular carcinoma (HCC) and malignant pleural mesothelioma (MPM). Pegargiminase is well tolerated, both as a monotherapy and as part of a combination therapy.
Lurbinectedin: PharmaMar
Lurbinectedin, also known as PM01183, or commercially where approved as Zepzelca® is an analogue of a similar natural compound ET-736 with characteristics that make it similar but different to its parent compounds. Lurbinectedin inhibits active transcription of protein-coding genes through binding to promoters and irreversibly stalling elongating RNA polymerase II on the DNA template, thereby leading to double-stranded DNA breaks and apoptosis.
YS110: Ys Therapeutics
YS110 is a recombinant humanized monoclonal antibody that binds with high affinity (dissociation constant, 0.244?nM) to human CD26. Extensive in vitro and in vivo studies have shown that YS110 possesses antitumor activity for malignant mesothelioma cell lines. Single or repeated intravenous administration of YS110 has also been found to be safe in nonhuman primates.YS110 is currently being investigated in Phase1/2 for the treatment of Malignant Pleural Mesothelioma.
Further product details are provided in the report……..
Malignant Pleural Mesothelioma: Therapeutic Assessment
This segment of the report provides insights about the different Malignant Pleural Mesothelioma drugs segregated based on following parameters that define the scope of the report, such as:
Major Players in Malignant Pleural Mesothelioma
There are approx. 20+ key companies which are developing the therapies for Malignant pleural mesothelioma. The companies which have their Malignant pleural mesothelioma drug candidates in the most advanced stage, i.e. phase III include, MolMed.
Phases
DelveInsight’s report covers around 20+ products under different phases of clinical development like
Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates
Route of Administration
Malignant Pleural Mesothelioma (MPM) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Oral
Parenteral
Intravitreal
Subretinal
Topical
Molecule Type
Products have been categorized under various Molecule types such as
Monoclonal Antibody
Peptides
Polymer
Small molecule
Gene therapy
Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
Malignant Pleural Mesothelioma (MPM): Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Malignant Pleural Mesothelioma (MPM) Therapeutic Market by key players involved in developing emerging drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Malignant Pleural Mesothelioma (MPM) drugs.
Malignant Pleural Mesothelioma (MPM) Report Insights
Malignant Pleural Mesothelioma (MPM) Pipeline Analysis
Therapeutic Assessment
Unmet Needs
Impact of Drugs
Malignant Pleural Mesothelioma (MPM) Report Assessment
Pipeline Product Profiles
Therapeutic Assessment
Pipeline Assessment
Inactive drugs assessment
Unmet Needs
Key Questions
Current Treatment Scenario and Emerging Therapies:
How many companies are developing Malignant Pleural Mesothelioma (MPM) drugs?
How many Malignant Pleural Mesothelioma (MPM) drugs are developed by each company?
How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Malignant Pleural Mesothelioma (MPM)?
What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Malignant Pleural Mesothelioma (MPM) therapeutics?
What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
What are the clinical studies going on for Malignant Pleural Mesothelioma (MPM) and their status?
What are the key designations that have been granted to the emerging drugs?
Share:
Introduction
Executive Summary
Malignant pleural mesothelioma: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Malignant pleural mesothelioma – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
Comparative Analysis
Pembrolizumab: Merck & Co
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Lurbinectedin: PharmaMar
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
DrugName: Company Name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
Drug Name: Company name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Malignant pleural mesothelioma Key Companies
Malignant pleural mesothelioma Key Products
Malignant pleural mesothelioma- Unmet Needs
Malignant pleural mesothelioma- Market Drivers and Barriers
Malignant pleural mesothelioma- Future Perspectives and Conclusion
Malignant pleural mesothelioma Analyst Views
Malignant pleural mesothelioma Key Companies
Appendix
List of Table
Table 1: Total Products for Malignant Pleural Mesothelioma (MPM)
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Malignant Pleural Mesothelioma (MPM)
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• MolMed
• PharmaMar
• Ys Therapeutics
• Merck Sharp & Dohme Corp.
• Kissei Pharmaceutical Co., Ltd.
• NovoCure Ltd
• AGC Biologics S.p.A
• Aduro Biotech, Inc
• Novartis
• Bristol-Myers Squibb
• Novartis
• TCR2 Therapeutics
• Novotech (Australia) Pty Limited
• AstraZeneca
• Hoffmann-La Roche
• Polaris Pharmaceuticals
• Kyorin Pharmaceuticals
• ACADIA Pharmaceuticals
Request Customization
Please request sample for more detailed Table Of Content and List of Figures
Research Methodology
SECONDARY RESEARCH
Secondary Research Information is collected from a number of publicly available as well as paid databases. Public sources involve publications by different associations and governments, annual reports and statements of companies, white papers and research publications by recognized industry experts and renowned academia etc. Paid data sources include third party authentic industry databases.
PRIMARY RESEARCH
Once data collection is done through secondary research, primary interviews are conducted with different stakeholders across the value chain like manufacturers, distributors, ingredient/input suppliers, end customers and other key opinion leaders of the industry. Primary research is used both to validate the data points obtained from secondary research and to fill in the data gaps after secondary research.
MARKET ENGINEERING
The market engineering phase involves analysing the data collected, market breakdown and forecasting. Macroeconomic indicators and bottom-up and top-down approaches are used to arrive at a complete set of data points that give way to valuable qualitative and quantitative insights. Each data point is verified by the process of data triangulation to validate the numbers and arrive at close estimates.
EXPERT VALIDATION
The market engineered data is verified and validated by a number of experts, both in-house and external.
REPORT WRITING/ PRESENTATION
After the data is curated by the mentioned highly sophisticated process, the analysts begin to write the report. Garnering insights from data and forecasts, insights are drawn to visualize the entire ecosystem in a single report.